Correlation between Epithelial Ovarian Cancer and Thrombocytosis
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摘要: 目的 :探讨卵巢上皮性癌与血小板(PLT)计数增高的相关性以及PLT计数增高的临床意义。 方法 :随机抽取2002年1月至2007年7月天津市中心妇产科医院收治的80例早期卵巢上皮性癌患者和50例晚期卵巢上皮性癌患者为研究对象,90例良性卵巢上皮性肿瘤患者为对照组。取患者术前、术后晨起空腹静脉血化验PLT和CA125,与各种临床资料进行统计分析。 结果 :早期卵巢上皮性癌患者PLT计数234.55±71.51(×109/L),晚期卵巢上皮性癌患者PLT计数308.12±111.95(×109/L),对照组PLT计数206.28±52.62(×109/L),三组间差异有显著性(P<0.05)。PLT计数增高患者手术残留癌灶≥2cm发生率高(P<0.05),手术后PLT计数下降(P<0.05)。早期卵巢上皮性癌不同病理类型与血PLT计数比较有显著性差异(P<0.05)。晚期卵巢上皮性癌不同的组织病理学分类、CA125、腹水量及淋巴结转移发生率与PLT计数无相关性。 结论 :卵巢上皮性癌PLT计数增高,手术后PLT降低;PLT增高患者手术困难、预后差,PLT计数与CA125升高无关,PLT计数增高可作为CA125之外的肿瘤标志物监测肿瘤的发生、发展,评估治疗效果和推测预后。Abstract: Objective : To evaluate the clinical significance of platelet count in epithelial ovarian cancer, and to investigate the correlation between an increase in platelet count and the incidence of epithelial ovarian cancer. Methods : Platelet count and pre- and post-operative CA125 were compared among three groups: the earlystage epithelial ovarian cancer group (n=80), the advanced stage epithelial ovarian cancer group (n=50) andthe benign ovarian tumor group (n=90). All patients were randomly recruited for the study between January2002 and July 2007. Results : The mean platelet count was 234.55±71.51 (×109/L) in the early stage epithelialovarian cancer group, 308.12 ± 111.95 (× 109/L) in the advanced stage epithelial ovarian cancer group, and 206.28±52.62 (×109/L) in the benign ovarian tumor group, with a significant difference among the 3 groups (P<0.05). There was a correlation between thrombocytosis and the incidence of residual tumor when the originaltumor diameter was greater than 2 cm. In general the platelet count was decreased after surgery. In the earlystage epithelial ovarian cancer group, the platelet count was correlated with histopathology. In the advancedstage epithelial ovarian cancer group, however, no correlation was found between platelet count andhistopathology, CA125, abdominal edema, or lymph node metastasis. Conclusion : An increased platelet countis commonly seen in patients with epithelial ovarian cancer, but it usually decreases after surgery. Patientswith thrombocytosis have a poor prognosis. Platelet count has no correlation with CA125, but it can be usedas a marker for the development and prognosis of epithelial ovarian cancer.
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Keywords:
- Epithelial ovarian cancer /
- Platelet count /
- Prognosis
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