Abstract: Objective : To explore the clinical and histopathological features of metanephric adenoma (MA). Methodse : The clinical and pathological data from 6 cases (4 males and 2 females, aged from 33 to 66 years, with an average age of 51 years) with MA were retrospectively analyzed and relevant literatures were reviewed. Only 1 patient had flank pain and malaise. All of the 6 patients were diagnosed with renal tumor by type-B ultrasonography and CT scan. Results : Five patients underwent radical nephrectomy and the other 1 patient had enucleation of the tumor. The average diameter of tumor was 4cm. Microscopical observation found that the tumors were composed of densely packed small uniform cells with regular nuclei that formed a tubular or adenoid pattern. Mitotic figures were absent or rare. Immunohistochemical staining showed that MA cells were positive for WT1 but negative for CK7 and EMA. Foci of papillary carcinoma were observed in 1 case. Follow-up (from 5 to 24 months) data were available in 5 cases and all of them were alive without recurrence. Conclusion : MA is a very rare primary renal tumor originating from epithelium. Understanding of its clinical and histological characteristics is helpful for making an accurate diagnosis. Nephron-sparing surgery is eligible for the treatment of MA. Considering the uncertainty of the biological behavior and cellular origin of MA, a long-term follow-up is necessary.