6例后肾腺瘤的临床与病理学特点分析

张晓光, 徐勇, 张淑敏, 张志宏, 杨阔, 权昌宜, 马宝杰

张晓光, 徐勇, 张淑敏, 张志宏, 杨阔, 权昌宜, 马宝杰. 6例后肾腺瘤的临床与病理学特点分析[J]. 中国肿瘤临床, 2008, 35(17): 984-987.
引用本文: 张晓光, 徐勇, 张淑敏, 张志宏, 杨阔, 权昌宜, 马宝杰. 6例后肾腺瘤的临床与病理学特点分析[J]. 中国肿瘤临床, 2008, 35(17): 984-987.
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ZHANG Xiaoguang, XU Yong, ZHANG Shumin, ZHANG Zhihong, YANG Kuo, QUAN Changyi, MA Baojie. Clinical and Pathological Characteristics of Metanephric Adenoma: a Report of 6 Cases[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(17): 984-987.
Citation: ZHANG Xiaoguang, XU Yong, ZHANG Shumin, ZHANG Zhihong, YANG Kuo, QUAN Changyi, MA Baojie. Clinical and Pathological Characteristics of Metanephric Adenoma: a Report of 6 Cases[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(17): 984-987.
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6例后肾腺瘤的临床与病理学特点分析

  • 天津医科大学第二医院泌尿外科, 天津市泌尿外科研究所, 天津市 300211

详细信息
    通讯作者:

    张晓光

  • 中图分类号: R737.11

Clinical and Pathological Characteristics of Metanephric Adenoma: a Report of 6 Cases

  • Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211, China

摘要

    摘要
  • 摘要: 目的 :探讨后肾腺瘤(metanephric denoma,MA)的临床及病理学特点。 方法 :结合文献回顾性分析6例MA患者的临床和病理资料。男4例,女2例。年龄33～66岁,平均51岁。右肾4例,左肾2例;仅1例表现为腰痛不摘要 目的 :探讨后肾腺瘤(metanephricdenoma,MA)的临床及病理学特点。 方法 :结合文献回顾性分析6例适、乏力,无其他阳性发现。6例均经B超、CT诊断为肾肿瘤。 结果 :5例行根治性肾切除,1例行肿瘤剜除术。肿瘤平均直径4cm。病理学特点:MA细胞均匀一致,排列成密集的小管状、腺样结构,胞浆少,无明显异形性,核分裂像罕见。免疫组化WT1(+),而EMA和CK7(-)。1例肿瘤局部出现乳头状腺癌成分。5例获随访5～24个月,均无瘤生存。 结论 :后肾腺瘤是一种罕见的肾脏原发上皮源性肿瘤,了解其临床及病理特点有助于该肿瘤的准确诊断。对该肿瘤治疗多采取保留肾单位的手术,但其生物学行为及细胞起源的不确定性决定对该病患者需进行长期的随访观察。
    Abstract: Objective : To explore the clinical and histopathological features of metanephric adenoma (MA). Methodse : The clinical and pathological data from 6 cases (4 males and 2 females, aged from 33 to 66 years, with an average age of 51 years) with MA were retrospectively analyzed and relevant literatures were reviewed. Only 1 patient had flank pain and malaise. All of the 6 patients were diagnosed with renal tumor by type-B ultrasonography and CT scan. Results : Five patients underwent radical nephrectomy and the other 1 patient had enucleation of the tumor. The average diameter of tumor was 4cm. Microscopical observation found that the tumors were composed of densely packed small uniform cells with regular nuclei that formed a tubular or adenoid pattern. Mitotic figures were absent or rare. Immunohistochemical staining showed that MA cells were positive for WT1 but negative for CK7 and EMA. Foci of papillary carcinoma were observed in 1 case. Follow-up (from 5 to 24 months) data were available in 5 cases and all of them were alive without recurrence. Conclusion : MA is a very rare primary renal tumor originating from epithelium. Understanding of its clinical and histological characteristics is helpful for making an accurate diagnosis. Nephron-sparing surgery is eligible for the treatment of MA. Considering the uncertainty of the biological behavior and cellular origin of MA, a long-term follow-up is necessary.
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出版历程
  • 收稿日期:  2008-05-15
  • 修回日期:  2008-07-25
  • 发布日期:  2008-09-14

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