Abstract: Objective: To investigate the effect of extraperitoneal laparoscopic radical prostatectomy on 33 patientswith prostate cancer. Methods: From February 2004 to September 2007, we performed eLRP on 33 patients(with an aver-age age of 69.8). All of the patients were diagnosed by pathology. Results: There were 4 cases of T1a ~1b(12%), 14 casesof T1c(42%), 5 cases of T2a-b(15%), and 10 cases of T2c(30%). The mean time period of operation was 4.6 hours. Themean blood loss was 419ml. Two cases received transfusion intraoperatively. Two cases received open surgery. Nine cases(27%) had positive surgical margins. Urine leak occurred in 3 cases, but was recovered without any intervention. Urinarycatheter duration was 14~45 days (18 days on average). No true incontinence was observed. Two cases had rectal injuryand underwent colostomy. The duration of follow up was 2~44 months(15.8 months on average). Serum PSA was 0~2.25ng/ml. No death occurred. Conclusion: With less complications and shorter time to recovery, extraperitoneal laparoscopicradical prostatectomy is an effective and safe approach for localized prostate cancer.