Abstract: Objective : To observe the in hibitio n of adhesion and invasion of SGC7901 to ECM by Integrinβ1 asODN. Methods : ODN were transfected into SGC7901, taking liposome as vector. The distributio n of ODN was recorded by im munochem istry, changes in the expression of Integrinβ1 mRNA and protein were determined by RT-P C R and FCM, respectively. The adhesion and invasion to ECM were measured by MTT and Boyden chamber method,respectively. Results : A fter Integrinβ1 asODN was transfected into SGC7901 it distributed evenly in cytoplasm and nucleus. PCR and FCM revealed a weakened band on 489bp and a shift-left curve,respectively. Adhesion and invasion assay also presented a decrease,with the in hibitin g rate of 54% and 76% . The extent of decrease induced by Integrinβ1 asODN was larger than that by the random ODN (P<0.001). Conclusion : Transfection of Integ rinβ1 asODN into SGc/901 induced a decrease in the expression of Integrinβ1 m RNA and protein, thus a decrease in adhesion and invasion to ECM , with a better effect than random ODN.