Abstract: Objective : To study the correlation between vascular endothelial growth factor and tumor-associated macrophages (TAMs) in angiogenesis of human oral squamous-cell carcinomas(OSCC). Methods : After immunohistochemical staining, light microscope was used for counting macrophages and microvessels, and automated image analysis quantification was used to detect VEG F expression. The double staining was also used to detect VEGF expression in TAMs. Results : VEG F expression show a significant positive connection with the counts of microvessels ( P<0.05, r=0.412) and macrophages (P<0.05, r=0.376) in OSCC. TAMs express VEG F in OSCC. Conclusions : VEG F expression, macrophage infiltration and angiogenesis may represents a important synergistic inter-relation between tumor cells and stroma in the micro- environment of OSCC.