Abstract: Objective : To determine clinical prognostic factors that accurately predict survival in patients with metastatic melanoma. Methods : 93 patients with metastatic malignant melanoma were analysed retrospectively. Results : 10.8% of all patients with distant metastasis of melanoma lived for more than 2 years. There was significant difference in 2-year survival rate between men and women,KPS≥80 and <80, liver and without liver involvement,one and multiple organ involvements, normal and elevated serum level of LDH, normal and decreased serum albumin, respectively. There was no difference between≥50 years and <50 years. Conclusion : Female, good performance status, without liver involvement, single organ metastase, normal LDH and albumin level, resection of the isolated focus are highly significant predictors of good survial.