Abstract: Objective : To investigate a more effective method for treatment intermediate or high grade non-Hodgkin Lymphoma (NHL). Methods : According to the diagnostic criteria of International Working Formulation (IWF), sixty-six cases were divided into two groups randomly, with thirty-one cases for the CHOP group and thirty-five cases for the COP-P group. The CHOP and TCOP were given with Pingyangmycin (TCOP-P) one time three weeks for six to eight courses, respectively. Results : The data showed that the total complete remission (CR) rate, partials remission (PR) rate and three-year survival rate of TCOP-P group were significantly greater than those of CHOP group; three-year recurrence rate and myocardial damage of TCOP-P group were lower than those of CHOP group. Conclusion :TCOP-P is an effective method for treatment intermediate or high grade NHL.TCOP-P can improve the rate of CR and prolong the survival time with reducing recurrence rate.