Abstract: Objective : Data of the Tianjin Cancer Registry was analyzed for exploring epidemic situation of leukemia from 1981 to 2000 in Tianjin. Methods : Cases diagnosed in the study were coded according to the ICD-0. Incidence and mortality rates were calculated by age, sex, and calendar year of onset and death of the cases. Results : 3334 incident cases and 1949 deaths of leukemia in Tianjin were registered from 1981 to 2000. The incidence rate and mortality rate of leukemia in Tianjin were 4.71 per 100,000 and 2.76 per 100,000 respectively. The incidence rates of leukemia in Tianjin did not change since 1981, but mortality rates decreased remarkably. Mortality and morbidity ratio also decreased. Acute myeloid leukemia,chronic myeloid leukemia, acute lymphoid leukemia and chronic lymphoid leukemia were the most common types of leukemia in Tianjin. Conclusion : The result of this study showed that early diagnosis and treatment of leukemia in Tianjin have been improved and further epidemiological research is needed to identify etiological factors of leukemia for its prevention.