Abstract: Objective : To clarify the plasma cellular adhesion characteristic in malignant tumorss, normal controls and non -malignant patients. Methods : Plasma cellular adhesion characteristic were detected by means of MTT coloremetry in 72 cases with malignant tumors, normal subjects and non malignant patients as controls. Results : The mean OD values of cell adhesion were significantly lower in cancer patients (0.061) than in the normal controls (0.081) and non malignant patients(0.07). Conclusion : Plasma cellular adhesion characteristic were claimed to be valuable markers in diagnosis and prognosis, and may also to play a role in prevention and treatment of metastasis clinically.