Abstract: Objective: To investigate the expression of Sorcin in primary breast cancer and determine whether such expression can predict survival. Methods: Expression of Sorcin in 60 breast cancer patients was determined by immunohistochemistry on formalin-fixed, paraffin-embedded tumor section. The relationship between the expression of Sorcin with the clinicophathological characteristics and the prognosis of breast cancer patients were also analyzed. Results: 1) Sorcin expression was observed in 34 of 60 (56.7%) cases. 2) No relation can be established between expression of Sorcin and clinicophathological parameters (P>0.05). 3) Kaplan-Meier analyses revealed that Sorcin expression didn't associated with disease-free survival (DFS) or overall survival (OS) (P>0.05). 4) In univariate and multivaiate COX regression analyses, tumor size, lymph node metastasis and estrogen receptor status were associated with DFS and OS (P<0.05). In addition, progestin receptor status was associated with OS (P<0.05). Conclusion: Sorcin is frequently expressed in primary breast carcinoma, but it isn't an independent predictive factor for DFS or OS.