63例40岁以下浸润性宫颈癌的临床与预后分析

The Clinical and Prognostic Analysis for 63 cases of Invasive Cervical Carcinoma Aged 40 and Younger

  • 摘要: 目的 :探讨40岁以下浸润性宫颈癌患者的临床与病理特征、预后及其影响因素。 方法 :对天津医科大学附属肿瘤医院1980年1月-1997年12月间收治的63例40岁以下浸润性宫颈癌(年轻组)资料进行回顾性分析,随机选取同期治疗的80例40岁以上病例(对照组)做对照研究。 结果 :40岁以下浸润性宫颈癌占全部宫颈癌的比例,由20世纪80年代初的1.8%,上升到1995年以后的16.0%。年轻组初婚年龄较高,孕次、产次较低,出现接触性出血症状的比例较高(P<0.01)。年轻组中腺癌的比例较高,组织分化程度较低(P<0.05),总的5年生存率(50.8%)低于对照组(72.5%,P<0.01),其中鳞癌的5年生存率(56.3%)明显低于对照组(79.7%,P<0.01)。年轻组的复发转移率(52.4%)明显高于对照组(32.5%,P<0.05),其中1年内复发转移的比例较高,平均发生复发转移的时间较短(P<0.05)。 结论 :影响40岁以下浸润性宫颈癌预后的因素与肿瘤大小、肿瘤外观、临床分期、组织学分级、病理类型及淋巴结转移有关。年轻妇女浸润性宫颈癌发病呈上升趋势,其预后较中老年组差。应提高对年轻妇女浸润性宫颈癌的警惕性,治疗中注重个体化的原则,对有高危因素的年轻患者提倡综合治疗。

     

    Abstract: Objective : To investigate the clinical and pathological features, prognosis and prognostic factors of invasive cervical carcinoma in women aged 40 and younger. Methods : 63 cases of invasive cervical carcinoma less than 40 years old were treated from 1980 to 1997, the record were retrospectively analysed, in control with 80 cases over 40 years at the same period. Results : The percentage of invasive carcinoma in young women increased from 1.8% to 16.0% in the last two decades. In the study group, the mean first mamage age were higher ,pregnancy and deliveiy numbers were lower. Compared with the control group, the percentage of contact bleeding symptom, adenocarcinoma type, low differentiated grade was higher in young women (P<0.05). The overall survival rate of 5 years in study group was 50.8% compared with 72.5% in control group (P<0.01). Young women cervical squamous carcinoma had poorer outcome, both the overall and stage II a/ H b/IH survival rate were lower than that of over 40 years. Recurrence and metastasis rate was strong higher in the study group (52.4%) than that in the control group(32.5%), the mean intei-vial from diagnosis to recurrence was 9.5 months versus 22.4 months in older group (P<0.05), and 66.7% recurrent in 1 year. Conclusions : The risk prognostic factors associated with invasive cervical carcinoma in young women included tumor maximum size (>4cm), endophytic and ulcerative tumor, advanced stage and grade, non-squamous carcinoma and pelvic lymph metastasis. There is an increasing prevalence of invasive cervical carcinoma in women under 40 years old. The prognosis is poorer than that in older women. Attention should be paid to young women with high risk factors of invasive cervical carcinoma, individual management and adequate therapy should be considered.

     

/

返回文章
返回