Abstract: Objective :To evaluate the efficacy of submucous layer infiltration injecting mechlorethamine to control the recurrence of bladder carcinoma. Methods :106 cases of bladder carcinoma (90 cases of non -infiltrated, 16 cases of infiltrated) were treated with partial cystectomy. chlormethine was injected to all the residual submucous during operation and irrigated MMC regularly postoperation. Results :The total rate of recurrence was 2.9K. None of 90 cases of non-infiltrated bladder carcinoma recured in five years, The rate of recurrence of 16 cases of infiltrated bladder carcinoma was 18.75%. Conclusions :The effect of submucous injecting chlormethine for controlling postoperative recurrence of bladder carcinoma is obvious and the technique is simpler, easier with minimal complications.