子宫颈癌组织中VEGF与TGF-β1间关系的探讨

Investigation of the Expression of Vascular Endothelial Growth Factor and Transforming Growth Factor-beta 1 in Cervical Cancer

    摘要
  • 摘要: 目的 :探讨血管内皮生长因子(VEGF)及转化生长因子(TGF-β1)在宫颈癌组织中的表达及其与宫颈癌临床病理特征的关系。 方法 :采用免疫组化链霉菌抗生物素蛋白-过氧化物酶连接染色法检测30例宫颈癌Ⅰ期、Ⅱ期患者癌组织中VEGF、TGF-β1的表达,并进行统计学分析。 结果 :VEGF、TGF-β1在宫颈鳞癌Ⅰ期、Ⅱ期均为高表达。VEGF在宫颈癌Ⅰ期、Ⅱ期、有淋巴转移者的表达率分别为78.3%、71.4%、100%。TGF-β1表达率分别为91.3%、42.9%、75.0%,其表达与年龄、肿瘤体积、浸润深度有关。 结论 :VEGF可促进肿瘤细胞的增生和转移;TGF-β1与肿瘤的发生、发展有关,可能使肿瘤细胞逃脱免疫监视。

     

    Abstract: Objective :To investigate the expression of vascular endothelial growth factor and transforming growth factor-beta 1 in cervical cancer tissues and the relationship between cervical cancer clinicopathologic character. Methods :Making use of immunohistochemistry to analyze the expression of VEGF, TGF-pi in 30 cervical cancer cases with statistics. Results :There are higher expression about VEGF and TGF-β1 in cervical squamous cancer ( I-Ⅱstage). Among them, the expression rate of VEGF in I stage, stage and tumor cells invasion lymph node is 78.3%, 71.4X and 100.0%, respectively; and the expression rate of TGF-β1 is 91.3%, 42.9% and 75.0%, respectively. The expression rate has the relationship with age, volume of tumor, depth of infiltration. Conclusion :VEGF may improve the cancer cells proliferation and spreading; TGF-β1 may lower immune function of body and result in cancer cells escaping from immune surveillanceP

     

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