Abstract: Objective : To detect the expression of vascular endothelial growth factor-C (VEGF-C) and its receptor VEGFR-3 (flt-4) in cervical diseases and inquire into the function of VEGF-C and flt-4 to the lymphangiogenesis and lymph node metastasis of cervical cancer. Methods : Seventy-eight cases of surgical speciments of cervical cancer in the hospital, in the period from 1998 to 2003, were collected and immunostained with VEGF-C and flt-4 polyclonal antibody by means of the streptavidin peroxidase method. Results : Of the 78 patients, the percentage of VEGF-C positive cells in cervical diseases ranged from 0～71%, 16 (20.5%) were negative, 21 (26.9%) weak positive, 26(33.4%) moderate positive and15 (19.2%) strong positive. The expression of VEGF-C became stronger and stronger with the progression of cervical diseases from chronical inflammation to cervical intraepithelial neoplasia(CIN) and to invasive carcinoma of cervix uteri. There was a direct correlation between the expression of VEGF-C and flt-4, both of VEGF-C and flt-4 were related to lymph node metastasis. Conclusion : VEGF-C may promote the canceration of cervical cancer. The VEGF-C/flt-4 system is closely related to the lymphangiogenesis and lymph node metastasis of cervical cancer.