Abstract: Objective : To discuss the value of application for endoscopic mucosal resection (EMR) on early gastroesophageal cancer and precancerous lesion. Methods : EMR was performed with a transparent cap in 89 patients between September 1996 and September 2003. All cases were confirmed histologically before and after operation. Results : Endoscopic follow-up was carried out in 17 patients for more than 5 years, 10 patients for 3 to 5 years and others for less than 3 years; no recurrence occurred and 5 patients died of other diseases during the period. Conclusion : The EMR procedure with the removal device is simpler and more efficacious than other method considerably; the display of lesions and the operating technique of EMR are main elements in influencing completive resection; the quantity of submucosal injection and using correctly on electrosurgical units can prevent complication; Medium dysplasia which does not improvement after a short-term follow up and severe dysplasia should be treated with EMR. The application of EMR is meaningful in the prevention and control of esophageal and gastric cancer.