Abstract: Objective :To study the clinical significance of FHIT expression in transition from normal cervical epithelia to cervical cancers and precancers. Methods :The expression of FHIT was detected by SP immunohistochemical methods on paraffin sections from 65 cervical carcinomas, 25 cervital intraepithelial neoplasia (CIN) samples, 14 chronic cervicitis samples and 5 normal cervix samAles. Results :Fhit protein expression was markedlyIuced or absent in 47 of 65 (72.31%) cervical carcinomas and 14 of 25 (56%) cervical intraepithelial neoplasia. In cervical carcinoma the loss of FHIT expression was significantly related to the tissue type and the cell grade (P<0.05), but not related to the depth of myometrium invasion and the clinical stage (P>0.05). Conclusions :he loss of FHIT expression is an early event in cervical tumorigenesis. The detection of FHIT protein may be used as a diagnostic biomarker for the earliest cervical precancers.