COX-2 iNOS及VEGF在胃不典型增生胃癌中的表达及其意义

The Significance of the Expression of COX-2, iNOS and VEGF in Gastric Atypical Hyperplasia and Gastric Cancer

    摘要
  • 摘要: 目的: 探讨COX-2、iNOS及VEGF在胃不典型增生及胃癌中的表达、相互关系及在胃癌中的作用. 方法: 采用免疫组化Power visionTM两步法对84例胃癌和54例胃不典型增生组织中COX-2、iNOS及VEGF的表达进行检测. 结果: COX-2、iNOS及VECF在胃癌中表达的阳性率分别为66.67%、77.38%、61.90%,均高于胃不典型增生组织(P<0.05).COX-2、iNOS及VEGF表达与肿瘤的大小、淋巴结转移呈正相关,COX-2、VEGF表达与肿瘤浸润深度呈正相关,VEGF与COX-2、iNOS的表达呈正相关(P<0.05). 结论: COX-2、iNOS及VEGF与胃癌的发生、浸润转移相关,COX-2、iNOS通过增强VEGF的表达而促进肿瘤血管生成及转移.

     

    Abstract: Objective :To explore the expression and the relationship of VEGF, COX-2 and iNOS protein in gastric cancer and atypical hyperplasia. Methods :The expression of VEGF, COX-2 and iNOS were determined with Power vision'" immunohistochemical analysis in 84 gastric cancers and 54 gastric atypical hyperplasia. Results : Positive rate of COX -2 (66.67%),iNOS (77.38%),VEGF (61.90%) in gastric cancer were significantly higher than those in gastric atypical hyperplasia (P<0.05). Overexpression of COX-2,iNOS and VEGF in gastric cancer was related to lymph node metastasis and tumor size (P<0.05). There was positive correlation between the expression of VEGF, COX-2 and iNOS. And the expression of COX-2 and VEGF was positive related to the invasion of gastric cancer . Conclusions :The expression of COX-2, iNOS, VEGF may play an important role in the occurrence and progress of gastric cancer.

     

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