Maspin BCSG1及c-erbB-2表达与乳腺癌预后的关系

The Relationship between the Maspin, BCSG1 and c-erbB-2 Expression and the Prognosis of Breast Cancer

摘要: 目的: 探讨Maspin、BCSG1、c-erbB-2蛋白在乳腺癌中的表达及其与预后的关系. 方法: 选取临床病理资料完整并随访5年以上的137例乳腺癌病例,采用SP免疫组织化学技术检测乳腺癌组织中的Maspin、BCSG1、c-erbB-2蛋白的表达情况,结合临床及病理形态学资料用COX模型分析Maspin、BCSG1、c-erbB-2表达对预后的影响. 结果: Maspin、BCSG1、c-erbB-2蛋白在乳腺癌组织中的阳性表达率分别为48.9%,67.2%,27.7%三者与生存时间显著相关(P<0.01). 结论: Maspin、BCSG1、c-erbB-2蛋白在乳腺癌中的表达与患者的生存期密切相关,可作为预测乳腺癌预后的参考指标.

Abstract: Objective : To assess the relationship between the Maspin, BCSG1 and c-erbB-2 expression and the prognosis in breast cancer. Methods :The expression of ER, PR, Maspin, BCSG1, cerbB-2 were determined with the SP immunohist chemical method in 137 cases with invasive breast cancer followed up over 5 years. Cox model was used to analyze the effect of Maspin, BCSG1 and cerbB -2 expression and the clinopathological manifestations and prognosis in breast cancer. Results :The expression rate of Maspin, BCSG1 and was 48.9%,67.2% and 27.7%,respectively, which were in relation with the survivals (P<0.01). Conclusions :The expression of BCSG1, cerbB-2and Maspin is closely related to the survival rate and can be used as the predictor of prognosis.