Abstract: Objective :To study the expression of proliferation cell nuclear antigen (PCNA) epidermal growth factor eptor (EGFR) transforming growth factor beta receptor type I and type II (TGFβR I TGF3R II)in human gastric carcinoma and its clinical significance. Methods : The expression of PCNA, EGFR, TGFβR I and TGFβR II in 38 gastric carcinomas was examined by immunohistochemical method. Results :The PCNA and EGFR were significantly higher and TGFβR I and TGFβRII were significantly lower in gastric carcinomas compared to normal gastric mucosa and paraneoplastic tissues (P<0.05); The expression of PCNA was related infiltration and metastasis to ymph nodes (P<0.05); The expression of EGFR was high and the expression of TGFβR I and of TGFβR II were low in the gastric carcinoma with large, poor differentiation, infiltration and metastasis to lymph nodes (P>0.05). Conclusions :The high expression of PCNA and EGFR and the low expression of TGFβR I and TGFβR II are related to gastric carcinogenesis and they may be useful to assess the biological behavior of Gastric Carcinoma.