Survivin在AFB1高暴露地区肝细胞癌中的表达及其临床意义

The Expression of Survivin mRNA and Its Clinical Significance in Hepatocellular Carcinoma of High Aflatoxin B1 Risk Area

摘要: 目的: 探讨Survivin在黄曲霉毒素B1(AFB1)高暴露地区肝细胞癌(HCC)发生发展中的作用。 方法: 用逆转录聚合酶链反应检测来自广西南部黄曲霉毒素B1高暴露地区患者手术切除肝癌及其癌旁组织中Survivin mRNA的表达情况。 结果: Survivin mRNA在55例HCC及其癌旁组织中的检出率分别为85.5%(47/55)及40.0%(22/55),两者差异有显著性(P<0.01)。Survivin mRNA在HCC组织中的表达率与临床分期(P<0.05)和肿瘤直径(P<0.05)相关。 结论: Survivin在HCC发生发展过程中起重要作用,HCC组织中的Survivin mRNA可作为AFB1高暴露地区HCC预后不良的参考指标。

Abstract: Objective : To investigate the roles of survivin in hepatocellular carcinoma (HCC) of high aflatoxin B1 risk area. Methods : The expression of survivin mRNA in 55 cases of HCC and adjacent liver tissues from high aflatoxin B1 risk area was determined by reverse transcriptase polymerase chain reaction. Results : The positive rate of survivin mRNA in the HCC tissue (85.5%, 47/55) was markedly higher than that of adjacent liver tissue (40.0%, 22/55) (P<0.01). There was a close corrrelation between the expression of survivin mRNA and the clinical stage (P<0.05) and diameter of tumor (P<0.05). conclusion : Survivin may play an important role in the development of HCC and survivin mRNA can be considered as a prognostic marker for HCC in high aflatoxin B1 risk area.