Abstract: Objective :To study the clinic characteristics and therapeutic modality of large celllung cancer (LCLC). Methods :Pathologic and clinical data of 47 inpatient cases in tumor center of Zhongshan university, from 1964-1999, were retrospectively reviewed. Results : LCLC accounted for 0.7% of all lung cancer patients in the corresponding term. The sex ratio between the male and the female patients was 23:1. The average survival time was 25 months. The 5-year survival rate was 19.1%, less than that of non-small cell lung cancer (28.2%). Conclusions :The therapeutic effectiveness of LCLC is poor, although it is a relatively less pathological type in lung cancer. Subdividing the pathology type of LCLC and standardized multimodality therapy maybe improve the therapeutic effectiveness of LCLC.