三种蒽环类抗肿瘤药物对K562/A02细胞体外抑制作用

The Effect of Three Anthracycline Antineoplastic Drugs on K562/A02 Cell Line Proliferation in vitro

摘要: 目的: 比较表阿霉素,柔红霉素和吡喃阿霉素对多药耐药细胞株K562/A02体外增殖的抑制作用. 方法: 利用MTT观察7.5～60μg/ml的表阿霉素或柔红霉素或吡喃阿霉素处理K562/A02细胞后细胞增殖的变化. 结果: 吡喃阿霉素剂量逐渐增大时,抑制率逐渐增强(P<0.05).吡喃阿霉素组对K562/A02细胞的抑制率较相同剂量表阿霉素组或柔红霉素组抑制率显著增加(P<0.01). 结论: 相同剂量的吡喃阿霉素较表阿霉素或柔红霉素有更强的抑制多药耐药细胞株K562/A02细胞的作用.

Abstract: Objective :To compare the effect of three kinds of anthracycline antineoplastic drugs cell line proliferation in vitro. Methods :MTT method 7.5 60 N.,g/ml cell line was was used to observe the alteration of the proliferation of K562/A02 cell line treated with Pirarubicin. Results :The inhibiting rate on K562/A02 Pharmorubicin or Daunorubicin or increased when the dose of Pirarubicin got higher candy higher than (P<0.05). The inhibition rate on K562/A02 cell line of Pirarubicin group was signifithat of the sa17e dose of Pharmorubicin or Daunorubicin (P<0.01). Conclusions :Pirarubicin has stronger inhibitive abilityon K562/A02 cell line proliferation than the same concentrationof Pharmorubicin or Daunorubicin in vitro.