P38蛋白在大肠癌中的表达及其临床意义

Expression of p38 Protein and Its Clinical Significance in Human Colorectal Carcinomas

    摘要
  • 摘要: 目的: 探讨人大肠癌中有丝分裂原激活蛋白激酶P38的表达及其临床意义。 方法: 应用免疫组织化学SABC法检测46例大肠癌组织及其癌旁正常粘膜中P38蛋白表达情况。 结果: P38蛋白的表达定位于胞质中,胞核中无表达。P38在大肠癌中的阳性表达率为95.65%,在癌旁组织中阳性表达率为33.13%。P38在大肠癌中的表达明显高于癌旁组织,有显著的统计学差异(P<0.01)。P38的表达与年龄、性别、肿瘤大小、肿瘤位置无明显相关(P>0.05)。P38的表达与Dukes分级,组织分化程度及有无淋巴结转移有显著差异(P<0.01)。 结论: 大肠癌组织中P38蛋白处于过度表达状态,与大肠癌的发生,发展和转移密切相关。

     

    Abstract: Objective : To investigate p38M APK protein expression and its clinical significance in human colorectal carcinomas. Methods : The samples were obtained from 46 cases with the disease.The expression of P38M APK protein was detected by im munohistochem istry, using the SABC staining method at the two sites: carcinoma tissue and its paraneoplastic tissue. Results : The expression of p38M APK protein was mainly localized in the cell cytoplasm and never in the nucleus. Positive rate of p38M APK protein expression was 95.65% in carcinoma tissues, 33.13% in its paraneoplastic tissue.The p38M APK protein expression in carcinoma tissue was significantly correlated with dukes stage, P<0.01, histology grade,P<0.01 and local lymph node ivolvement, P<0.01, but not w ithage, gender, site or size of tumor, P>0.05. conclusion :p38 may play anim portant role in the occurrence, developmentand metastasis of human colorectal carcinoma.

     

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