Low-grade Myofibrosarcoma: A Clinicopathologic Study
-
摘要: 目的:探讨低度恶性肌纤维母细胞肉瘤(LGMS)的临床病理特征及其治疗。方法:分析9例LGMS的临床和病理特征,并进行免疫组化标记。结果:9例均行手术切除,其中3例第一次手术为广泛切除术。本病肿瘤细胞特点为胞浆嗜酸而核两端尖,弥漫性广泛表达SMA和MSA。7例获随访资料,2例分别于术后5个月和7年复发,后者半年后2次复发并转移至舌。结论:LGMS是光镜下可辨认的低度恶性肉瘤,其临床重要性在于与假肉瘤性病变鉴别,手术切除干净并密切随访以避免复发。
-
关键词:
- 低度恶性肌纤维母细胞肉瘤 /
- 免疫组化 /
- 诊断
Abstract: Objective :To study the clinicopathologic features and treatments of low-grade myofi-brosarcoma (LGMS). Methods :The clinical and pathologic features of 9 cases with LGMS were analyzed using immunohistochemistry. Results : All patients were treated surgically, among which three of them were initially treated by wide excision. The tumor cells, with eosinophilic cytoplasm and tapered nuclei, were diffusely strong positive for SMA and MSA. Follow-up in 7 patients (median:) revealed recurrence in two cases 5 months and 7 years after local excision, and further recurrence and tongue metastases in the latter one 6 months after the re-excition. Conclusions : It has been confirmed in this research that LGMS is a low-grade malignant tumor, which can be recognized at light microscopy. The clinical significance is to avoide confusion with psuedosarcomatous conditions. Complete surgical resection and close follow-up are both necessary in the treatment to avoid recurrences.-
Keywords:
- Myofibroblstic sarcoma /
- Immunohistochemistry diagnosis
-
-
[1] 1 Fletcher CDM, Unni KK, Mertens F. World health organization classification of tumors. Pathology and genetics. Tumors of soft tissue and bone[M]. Lyon: IARCP Press, 2002. 94-95
2 Fisher C. Myofibrosarcoma [J]. Virchows Arch, 2004, 445(3): 215-223
3 王坚,王丽珍,李江,等.低度恶性肌纤维母细胞性肉瘤[J].临床与实验病理学杂志,2003,19(4):347-351
4 Guillou L, Coindre JM, Bonichon F, et al. Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma [J]. J Clin Oncol, 1997, 15 (1): 350-362
5 Schurch W, Seemayer TA, Gabbiani G. The myofibroblast. A quarter century after its discovery [J]. Am J Surg Pathol, 1998, 22(2): 141-147
6 Eyden BP. Electronic microscopy in study of myofibroblastic lesions[J]. Semin Diagn Pathol, 2003, 1(2): 13-24
7 Watanabe K, Ogura G, Tajino T, et al. Myofibrosarcoma of the bone: a clinicopathologic study [J]. Am J Surg Pathol, 2001,25(12): 1501-1507
8 Fletcher CDM. Myofibroblastic sarcoma (author's reply to letter) [J]. AmJ SurgPathol, 1999, 23(11): 1433-1435
9 Mentzel T, Dry S, Katenkamp D, et al. Low-grade myofibroblastic sarcoma: analysis of 18 cases in the spectrum of myofibroblastic tumors[J]. AmJ SurgPathol, 1998, 22(10): 1228-1238
10 Montgomery E, Goldblum JR, Fisher C. Myofibrosarcoma: a clinicopathologic study[J]. AmJ Surg Pathol, 2001, 25(2): 219-228
计量
- 文章访问数: 21
- HTML全文浏览量: 4
- PDF下载量: 11
下载:
