Abstract: Objective :To evaluate efficacy and toxicity of the regimen of oxaliplatin combined with Epirubicin and SFu/LV (EOF) in treatment of patients with advanced gastric cancer. Methods :Thirty-seven patients who was pathologically confirmed as advanced gastric cancer received chemotherapy of the regimen: Epirubicin SOmg/mz 2h dl, Oxaliplatin 85mg/mz 2h dl, Lecovorin (LV)200m IV 2h dl一3,SFu 500mg/mZ Civ 22h dl-3 civ repeated, every 3 weeks for at least 3 cycles. Results : Thirty-seven patients were enrolled,of which 36 were evaluable for efficacy and toxicity. Mean age was 52 years old, 28 cases for men, 8 cases for women. Totally 130 cycles were received, average 3.6 cycles per patient. Among them CR 2 patients, PR 13 patients, the overall response rate (CR+PR) was 41.7%, SD 47.2%, PD 11.1%, IMPS improve for 38.9%(14/36), CBR improve for 50.0%. The main toxicity was bone marrow suppression: Neutropenia 19.4%,Thymocytopenia 11.1%,Anemia 8.3%; nausea and vomiting 8.3%, diarrhea 2.8%;III 0 Neuropathy 11.1%. Conclusions :The EOF regimen is effective and tolerable in treatment advanced gastric cancer.