Abstract: Objective: To study the observation on the curative effect of pre-operation neoadjuvant chemotherapy for bulky cervical carcinoma. Methods: A total of 20 cases with bulky cervical carcinoma were treated during January 2000 to February 2004. The chemotherapy adopted was DDP 20mg/m² intravenous injection from 1st to 5th day; BLM 10mg/m² muscle or intravenous injection at 1st, 3rd and 5th day; HCPT 6-10mg intravenous injection from 1st to 5th day. After chemotherapy, 19 cases were treated with radical surgery. Results: The 20 cases of bulky cervical carcinoma were treated with NACT, the CR+PR was 70%, CR+PR+Impr was 95%. Two cases of them had an ideal effect, the partial tumor was basically eliminated, and only with cervical corruption. Conclusion: Before operation, the chemotherapy plan DDP+BLM+HCPT is adopted, which can reduce or eliminate partial cervical tumors, thus can increase success rate of operation, and can extend the survival period of patients.