Abstract: Objective: To observe treatment effetiveness of Ⅲ and Ⅳstage T- NHL using CCCG regimen. Methods: From Sept 1998 to Sept 2002, 24 cases with Ⅲ and Ⅳ stage T-NHL were admitted in the hospital. According indications, examination before treatment and assessment standard about effectiveness, 11 cases were brought into this CCCG regimen group. Results: Continuous remission occurred in seven cases and the longest time of CR was 58 months; the remaining four were dead (among which two have kept continuous remission for 15 and 24 months respectively and they died of recurrence; one died of drug toxicity and one died of progression). Conclusion: CCCG regimen can improve survival rate and prolong survival time. Because of drug toxicity and serious myelosuppression, it is difficult to be generalized widespreadly in hospitals at lower level.