Abstract: Objective: To analyze the independent clinical prognostic factors of children patients with yolk sac tumor and to review related literatures. Methods: A total of 30 children patients with yolk sac tumor hospitalized between Jan 1989 to Dec 2002 were followed- up and six clinical factors,including age, sex, primary site, Brodeur stage, serum AFP and selection of chemotherapy regimen were statistically analyzed. Results: The independent clinical factors, such as Brodeur stage and selection of chemotherapy regimen, can affect 2- year event- free survivals (EFS) of yolk sac tumor in children. The 2- year EFS of Brodeur stage Ⅰ~Ⅳ was 76.92%, 66.67%, 40.00% and 0.00%, and that of VAC and BEP regimen were 18.18% and 73.68%, respectively. There was the stastisical significances. Conclusions: Multi- modality management such as surgery and adjuvant chemotherapy was optimal for the patients with yolk sac tumor in children and adolescent. No residual tumor left after operation is the aim of surgery. Those with unresectable tumor can also receive wide margine excision after neoadjuvant chemotherapy. The appropriate adjuvant chemotherapy is needed and can improve the curative effect by BEP regimen, but enhancement for the outcomes of cases with recurrence and metastasis is still expected.