血清IL-10水平与鼻咽癌生物学行为的关系

李先明, 徐钢, 陈亦欣, 吴冬, 闫茂生, 田野

李先明, 徐钢, 陈亦欣, 吴冬, 闫茂生, 田野. 血清IL-10水平与鼻咽癌生物学行为的关系[J]. 中国肿瘤临床, 2005, 32(18): 1040-1041,1048.
引用本文: 李先明, 徐钢, 陈亦欣, 吴冬, 闫茂生, 田野. 血清IL-10水平与鼻咽癌生物学行为的关系[J]. 中国肿瘤临床, 2005, 32(18): 1040-1041,1048.
Li Xianming, Xu Gang, Chen Yixin, . The Correlation between the Level of Serum Interleukin-10 and Clinical Biological Behavior in Nasopharyngeal Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2005, 32(18): 1040-1041,1048.
Citation: Li Xianming, Xu Gang, Chen Yixin, . The Correlation between the Level of Serum Interleukin-10 and Clinical Biological Behavior in Nasopharyngeal Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2005, 32(18): 1040-1041,1048.

血清IL-10水平与鼻咽癌生物学行为的关系

详细信息
    作者简介:

    李先明, 在读研究生;田野, 苏州大学附属第二医院放疗科

  • 中图分类号: R739.63

The Correlation between the Level of Serum Interleukin-10 and Clinical Biological Behavior in Nasopharyngeal Carcinoma

  • 摘要: 目的:探讨血清IL-10水平与鼻咽癌生物学行为的关系。方法:采用ELISA法检测60例鼻咽癌患者和20例正常者血清IL-10水平。结果:鼻咽癌组患者血清IL-10水平明显高于正常对照组(P<0.005);Ⅰ和Ⅱ期患者血清IL-10水平明显低于Ⅲ和Ⅳ期患者(P=0.011);有颈淋巴结转移或远处转移患者的血清IL-10水平稍高于无颈淋巴结转移或无远处转移患者,但差异无统计学意义(P>0.05)。结论:血清IL-10水平的升高可能涉及鼻咽癌的发生和发展过程。
    Abstract: Objective: To investigate the correlation between the level of serum interleukin-10 (IL-10) and clinical biological behavior in nasopharyngeal carcinoma (NPC). Methods: The level of serum IL-10 was detected by ELISA in 60 patients with NPC and 20 cases in the control group. Results: The level of serum IL-10 in NPC was significantly higher than that in the control group (P<0.005). The level of serum IL-10 for the patients in stageⅠand Ⅱwas significantly lower than that for the patients in stage Ⅲ and Ⅲ (P=0.011). The level of serum IL-10 in patients with lymph node metastases or distant metastases was higher than that in patients without lymph node metastases or distant metastases, but no statistically significance was observed. Conclution: Rising level of serum IL-10 may play an important role in the development of NPC, and further studies may be necessary to determine the value of the level of serum IL-10 in NPC.
  • [1] 1 Yue FY, Dummer R, Geertsen R, et al. Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class- Ⅰ, HLA class- Ⅱ and ICAM- 1 molecules [J]. Int J Cancer, 1997, 71(4): 630~ 637
    2 Boyano MD, Garcia-Vazquez MD, Lopez Michelena T, et al. Soluble interleukin- 2 receptor, intercellular adhesion molecule- 1 and interleukin- 10 serum levels inpatients with melanoma[J]. Br J Cancer, 2000, 83(7): 847~ 852
    3 Galizia G, Lieto E, De Vita, et al. Circulating levels of interleukin- 10 and interleukin- 6 in gastric and colon cancer patients before and after surgery: relationship with radicality and outcome [J]. J Interferon Cytokine Res, 2002, 22(4): 473~ 482
    4 Sharma S, Stolina M, Lin Y, et al. T-cell derived IL-10 promotes lung cancer growth by suppressing both T-cell and APC function[J]. J Immunol, 1999, 163(9): 5020~ 5028
    5 Knolle PA, Uhrig A, Hegenbarth S. IL- 10 down-regulates T-cell activation by anti- presenting liver sinusoidal endothelial cells through decreased antigen uptake via the mannose receptor and lowered surface expression of accessory molecules [J]. Clin Exp Immunol, 1998, 114(3): 427~ 433
    6 Groux H, Bigler M, De Vries. Inhibitory and stimulatory effects of IL- 10 on human CD8+ T cell [J]. J Immunol, 1998, 160(7): 3188~ 3193
    7 Steinbrink K, Jonuleit H, Muller G, et al. Interleukin-10 treated human dendritic cells induce a melanoma antigen specific anergy in CD8+ T cell resulting in a failure to lyse tumor cells[J]. Blood, 1999, 93(5): 1634~ 1642
    8 Elnemr A, Ohta T, Yachie A, et al. Human pancreatic cancer cells express non- functional Fas receptors and counterattack lymphocytes by expressing Fas ligand; a potential mechanism for immune escape[J]. Int J Oncol , 2001, 18(1): 33~ 39
    9 齐法莲,徐 军,杜秀敏,等.肺部良恶性疾病手术前后血清 IL- 10测定的临床意义[J].放射免疫学杂志,2003,16(4):198~ 200
    10 刘振玉,方向明,路作新,等.IL- 10 在肺癌细胞中表达的意义及其影响因素的探讨[J].实用癌症杂志,2000,15(5):489~ 491
    11 金 涌,朱金水,陈维雄,等. 腹腔免疫化学对晚期结肠癌癌性腹水患者 IL- 6 及 IL- 10 影响[J].中国临床医学,2002,9(5):519~ 520
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出版历程
  • 收稿日期:  2005-04-17
  • 修回日期:  2005-07-19
  • 发布日期:  2005-09-29

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