Abstract: Objective :To investigate clinical characteristics of pheochromocytomas, includingatypical and complicated pheochromocytomas and to summarize the experience of diagnosis, differentialdiagnosis and treatment. Methods :Clinical features of manifestation, sign, laboratory test and imaging examinations were retrospectively analyzed in 221 patients with pheochromocytoma. Results :This group included 99 male and 122 female with an average age of 43.7. The tumors were discovered in three pabents by routine examination, 15 by gastrointestinal symptoms, three by follow- up and 105 by hypertension. The symptomatic pheochromocytomas were identified in 176 patients, 21 were static pheochromocytomas, 15 were extra- adrenal pheochromocytomas (8 of them were multiple pheochromocytomas),17 were multiple pheochromocytomas and 13 were confirmed as malignancies in total 221 patients. Conclusions :Laboratory test is essential for symptomatic pheochromocytomas. Imaging examination is important and practical to distinguish static pheochromocytoma from incidentalomas. Extra-adrenal pheochromocytomas are often multicentric and have greater malignant potential. Recurrence rate is high in extra-adrenal and multicentric pheochromocytomas. Extra-adrenal, multicentric and recurrentpheochromocytomas have high potential malignancy. Sur cal removal of tumor is the choice of treat-ment for all types of pheochromocytomas.