局限期小细胞肺癌锁骨上区机率研究

The Study on Probability of the Supraclavicular Metastasis for Small Cell Lung Cancer at Limited Stage

  • 摘要: 目的: 通过对30例局限期小细胞肺癌患者的照射体积的研究,探讨锁骨上区转移机率。 方法: 对我科1999年11月~2002年5月收治的30例全部经病理证实、及胸部、腹部肝、肾上腺、头部CT扫描、骨扫描确诊的局限期小细胞肺癌(LS-SCLC)患者,且无锁骨上区淋巴结转移,在化疗6个周期内进行肺部原发灶、同侧肺门、纵隔的照射,常规分割照射40Gy后缩野加量至60Gy,所有病例进行了2~3年半的随访。 结果: 30例局限期小细胞肺癌患者经过放化疗综合治疗后发生3例颈部淋巴结转移,90%未发生颈部淋巴结转移,2年生存率43%。 结论: 对局限期小细胞肺癌患者采取放化疗综合治疗时,可以考虑不进行颈部预防照射。

     

    Abstract: Objective :To discuss the probability of supraclavicular metastasis in the limited-stage small cell lung cancer (LS- SCLC) through the studies on the irradiated volume in 30 patients withthe disease. Methods :During the period from Nov 1999 to May 2002, 30 patients with LS- SCLC wereadmitted and treated here in the department. All the cases wire followed up for 2 to 3 years and a half,who wire pathol cally confirmed and were diagnosed by CT scan and bone scan in the chest, the liv-er and adrenal gland at abdomen, and the head, with no lymphatic metastasis in supraclavicular reon.Irradiation in the primary focus of lung, homolateral hilum of lung and mediastinum were conductedduring the 6 cycles of chemotherapy, and the reduced field was increased to 60 Gys after conventionalfractionated irradiation with 40 Gys. Results :After the combined treatment of chemoradiotherapy on 30 patients with small cell lung cancer at limited stage, no metastases at lymph node of neck occurs in90% of them, apart from 3 cases. Conclusions :Prophylactic irradiation on neck may be irrespective as the combined treatment of chemoradiotherapy on the patients with small cell lung cancer at limitedstage.

     

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