Abstract: Objective : To examine the serum level of SCCAg and its clinical significance, as well as the relationship between the serum level of SCCAg and the pathphysiological characteristics in cervical carcinoma. Methods The serum level of SCCAg was detected in 145 patients with cervical carcinoma using ELISA. Results : 1) The abnormal SCCAg levels in diagnosis of squamous cell carcinoma of the cervix showed a sensitivity of 77.24% and specificity of 98%. The positive detection rate was significantly higher in stage Ⅲ～Ⅳ (87.71%) than that in stage Ⅰ-Ⅱ (66.67%) (P0.005). 2) After treated, the serum concentration of SCCAg (0.235±0.178ng/mL) was significantly lower than that in untreated patients (5.048±6.234ng/mL), (P0.001). 3). In metastasis patients, the serum level of SCCAg (9.372±10.252ng/mL) was significantly higher than that in untreated patients (5.048±6.234ng/mL) (P0.001). 4). The untreated serum level of SCCAg in cervical carcinoma patients was closely related to P-TNM stages, Intravascular infiltration, metastasis of pelvic lymph node (P0.01-P0.001), but not to the patients age, histological type and modality of growth (P0.1). Conclusion : SCCAg is helpful in diagnosing cervical carcinoma. They can serve as criteria of prognosis. SCCAg monitoring is valuable in the treatment of patients with cervival carcinoma.