库肯勃瘤中CD44v6﹑VEGF﹑MMP-2﹑MMP-9的表达及相关性研究

高颖, 娄阁

高颖, 娄阁. 库肯勃瘤中CD44v6﹑VEGF﹑MMP-2﹑MMP-9的表达及相关性研究[J]. 中国肿瘤临床, 2005, 32(24): 1381-1385.
引用本文: 高颖, 娄阁. 库肯勃瘤中CD44v6﹑VEGF﹑MMP-2﹑MMP-9的表达及相关性研究[J]. 中国肿瘤临床, 2005, 32(24): 1381-1385.
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Gao Ying, Lou Ge. Expression and Relativity Study of CD44v6, VEGF, MMP-2 and MMP-9 in Krukenberg Tumor[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2005, 32(24): 1381-1385.
Citation: Gao Ying, Lou Ge. Expression and Relativity Study of CD44v6, VEGF, MMP-2 and MMP-9 in Krukenberg Tumor[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2005, 32(24): 1381-1385.
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库肯勃瘤中CD44v6﹑VEGF﹑MMP-2﹑MMP-9的表达及相关性研究

  • 哈尔滨医科大学附属肿瘤医院妇科, 哈尔滨市 150040

详细信息
    通讯作者:

    娄阁,dr-lg911@163.com

  • 中图分类号: R737.31

Expression and Relativity Study of CD44v6, VEGF, MMP-2 and MMP-9 in Krukenberg Tumor

  • Department of Obstetrics and Gynecology, Tumor Hospital of Harbin Medical University, Harbin

摘要

    摘要
  • 摘要: 目的:探讨CD44v6、VEGF、MMP-2、MMP-9在库肯勃瘤及卵巢原发上皮癌中的表达及相关性。方法:应用免疫组化SP法检测CD44v6、VEGF、MMP-2、MMP-9在20例正常卵巢组织、38例库肯勃瘤、45例卵巢原发上皮癌中的表达情况。结果:CD44v6、VEGF在卵巢原发上皮癌和库肯勃瘤组织中的表达显著高于正常卵巢组织(P<0.05);MMP-2﹑MMP-9在正常卵巢组织中表达缺如;CD44v6、VEGF、MMP-2、MMP-9在库肯勃中阳性表达率明显高于卵巢原发上皮癌(P<0.05)。CD44v6、VEGF、MMP-2、MMP-9在卵巢原发上皮性癌、库肯勃瘤中,任意两指标阳性表达均有正相关性(P<0.05)。结论:CD44v6、VEGF、MMP-2、MMP-9均参与卵巢癌、胃癌、库肯勃瘤的发生、发展及演进过程,并可为卵巢上皮癌、胃癌及库肯勃瘤的鉴别诊断提供一定依据。
    Abstract: Objective: To explore expression and relativity of CD44v6, VEGF, MMP-2 and MMP-9 in Krukenberg and the primary epithelial ovarian carcinoma.Methods: The expressions of CD44v6,VEGF, MMP-2 and MMP-9 were detected by immunohistochemistry S-P method in the 20 cases ofnormal ovarian tissues, 38 cases with Krukenberg tumor and 45 cases with primary epithelial ovariancarcinoma.Results: The expressions of CD44v6 and VEGF were significantly higher in primary epithe-lial ovarian carcinoma tissues and Krukenberg tumor tissues than in normal ovarian tissues (P<0.05).The positive expression rates of MMP-2 and MMP-9 were zero in the normal ovarian tissues. The posi-tive expression rates of CD44v6, VEGF, MMP-2 and MMP-9 were remarkably higher in the Kruken-berg tumor than in primary epithelial ovarian carcinoma (P<0.05). Relativity has been observed forCD44v6, VEGF, MMP-2 and MMP-9 each other in primary epithelial ovarian carcinomas and inKrukenberg tumors (P<0.05).Conclusion: CD44v6, VEGF, MMP-2 and MMP-9 were concerned withevolvement process for ovarian carcinoma, gastric cancer and Krukenberg tumor. Detection of CD44v6,VEGF, MMP-2 and MMP-9 may offer basis of diagnosis ovarian carcinoma, gastric cancer and Kruken-berg tumor.
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  • [1] 1 Zhao GH, Li TC, Shi LH, et al. Relationship between inactiva-tion of p16 gene and gastric carcinoma [J]. World J Gastroenterol,2003, 9(5):905-909
    2. 全国胃癌病理协作组.360 例胃癌尸检材料病理学研究 [J]. 中华病理学杂志 ,1983, 12(2):124-128
    3. Conti CJ. Vascular endothelial growth factor: regulation in themouse skin carcinogenesis model and use in antiangiogenesis can-cer therapy[J]. Oncologist, 2002, 7(Suppl 3):4-11
    4. Junglin B, Menges M, Goebel R, et al. Expression of CD44v6 has no prognostic value in patients with colorectal cancer [J]. Z Gas-troenterol, 2002, 40(4):229-233
    5. Waas ET, Lomme RM, DeGroot J, et al. Tissue levels of activematrix metalloproteinase-2 and -9 in colorectal cancer [J]. Br JCancer, 2002, 86(12):1876-1883
    6. 李巨,刘佳,卢海鸥,等.卵巢肿瘤中 CD 44 变异型的免疫组织化学分析 [J]. 中国肿瘤临床 ,1998, 25(10):738-741
    7. Yamaguchi A, Goi T, Yu J, et al. Expression of CD44v6 in ad-vanced gastric cancer and its relationship to hematogenous metas-tasis and longterm prognosis[J]. J Surg Oncol, 2002, 79(4): 230-235
    8. Giavazzi R, Sennino B, Coltrini D, er al. Distinct role of fibroblastgrowth factor-2 and vascular endothelial growth factor on tumorgrowth and angiogenesis [J]. Am J Pathol, 2003, 162 (6): 1913-1926
    9. Taraboletti G, Poli M, Dossi R, et al. Antiangiogenic activity ofaplidine, a new agent of marine origin [J]. Br J Cancer, 2004, 90(12):2418-2424
    10. Gadducci A, Viacava P, Cosio S, et al. Vascular endothelialgrowth factor (VEGF) expression in primary tumors and peri-toneal metastases from patients with advanced ovarian carcinoma[J]. Anticancer Res, 2003, 23(3C):3001-3008
    11. Linderholm BK, Lindh B, Beckman L, et al. Prognostic correla-tion of basic fibroblast growth factor and vascular endothelialgrowth factor in 1307 primary breast cancers[J]. Clin Breast Can-cer, 2003, 4(5):340-347
    12. Kabashima S, Msehara Y, Kakeji Y, et al. Clinicopathological fea-tures and overepression of matrix metalloproteinases in intramu-cosal gastric carcinoma with lymph node metastasis[J]. Clin Can-cer Res, 2000, 6(9):3581-3584
    13. Hirvonen R, Talvensaari-Mattila A, Paakko P, et al. Matrixmetalloproteinase-2 (MMP-2) in T (1-2) NO breast carcinoma[J]. Breast Cancer Res Treat, 2003, 77(1):85-91
    14. Takahashi Y, Kitadai Y, Ellis LM, et al. Multiparametric in situmRNA Hybridization Analysis of Gastric Biopsies PredictsLymph Node Metastasis in Patients with Gastric Carcinoma [J].Jpn J Cancer Res, 2002, 93(11):1258-1265
    15. Wang L, Zhang LH, Li YL, et al. Expression of MMP-9 andMMP-9 mRNA in gastric carcinoma and its correlation with an-giogenesis[J]. Zhonghua Yi Xue Za Zhi, 2003, 83(9):782-786
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出版历程
  • 收稿日期:  2005-01-26
  • 修回日期:  2005-08-24
  • 发布日期:  2005-12-30

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