库肯勃瘤中CD44v6﹑VEGF﹑MMP-2﹑MMP-9的表达及相关性研究

Expression and Relativity Study of CD44v6, VEGF, MMP-2 and MMP-9 in Krukenberg Tumor

    摘要
  • 摘要: 目的:探讨CD44v6、VEGF、MMP-2、MMP-9在库肯勃瘤及卵巢原发上皮癌中的表达及相关性。方法:应用免疫组化SP法检测CD44v6、VEGF、MMP-2、MMP-9在20例正常卵巢组织、38例库肯勃瘤、45例卵巢原发上皮癌中的表达情况。结果:CD44v6、VEGF在卵巢原发上皮癌和库肯勃瘤组织中的表达显著高于正常卵巢组织(P<0.05);MMP-2﹑MMP-9在正常卵巢组织中表达缺如;CD44v6、VEGF、MMP-2、MMP-9在库肯勃中阳性表达率明显高于卵巢原发上皮癌(P<0.05)。CD44v6、VEGF、MMP-2、MMP-9在卵巢原发上皮性癌、库肯勃瘤中,任意两指标阳性表达均有正相关性(P<0.05)。结论:CD44v6、VEGF、MMP-2、MMP-9均参与卵巢癌、胃癌、库肯勃瘤的发生、发展及演进过程,并可为卵巢上皮癌、胃癌及库肯勃瘤的鉴别诊断提供一定依据。

     

    Abstract: Objective: To explore expression and relativity of CD44v6, VEGF, MMP-2 and MMP-9 in Krukenberg and the primary epithelial ovarian carcinoma.Methods: The expressions of CD44v6,VEGF, MMP-2 and MMP-9 were detected by immunohistochemistry S-P method in the 20 cases ofnormal ovarian tissues, 38 cases with Krukenberg tumor and 45 cases with primary epithelial ovariancarcinoma.Results: The expressions of CD44v6 and VEGF were significantly higher in primary epithe-lial ovarian carcinoma tissues and Krukenberg tumor tissues than in normal ovarian tissues (P<0.05).The positive expression rates of MMP-2 and MMP-9 were zero in the normal ovarian tissues. The posi-tive expression rates of CD44v6, VEGF, MMP-2 and MMP-9 were remarkably higher in the Kruken-berg tumor than in primary epithelial ovarian carcinoma (P<0.05). Relativity has been observed forCD44v6, VEGF, MMP-2 and MMP-9 each other in primary epithelial ovarian carcinomas and inKrukenberg tumors (P<0.05).Conclusion: CD44v6, VEGF, MMP-2 and MMP-9 were concerned withevolvement process for ovarian carcinoma, gastric cancer and Krukenberg tumor. Detection of CD44v6,VEGF, MMP-2 and MMP-9 may offer basis of diagnosis ovarian carcinoma, gastric cancer and Kruken-berg tumor.

     

    • HTML全文
    • 参考文献(1)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回