Abstract: Objective: To study therapeutic measures of the unresectable primary liver cancer(PLC).Methods: From January 1991 to March 2000, the clinical data of 254 patients with unresectableprimary liver cancer were analyzed retrospectively.Results: Seventy patients with unresectable primaryliver cancer were treated by cryosurgery combined therapy. One hundredand and ninety-two patientswith unresectable primary liver cancer were treated by a TACE oriented comprehensive therapy. Twohundred and thirty-one patients were followed-up from 2 months to 132 months. The 1-, 3-and 5-year survival rate in the cryosurgery group were 63.2%, 37.1% and 25.8%, respectively. The 1-, 3-and 5-year survival rates in the 13 cases with second-stage resection were 100%, 76.9% and 53.8%,respectively. The 1-, 3-and 5-year survival rates in the TACE group were 73.4%, 27.1% and 9.3%,respectively. The overall 1-, 3-and 5-year survival rates were 70.9%, 29.5% and 13.4%, respectively.Conclusions: Curative effect of unresectable primary liver cancer should be raised by an individual,reasonable and ordered comprehensive therapy.