Abstract: Objective: To explore the curative effect of percutaneous cryoablation (PTC) in treat-ment of metastatic liver malignancy.Methods: A total of 22 patients with the metastatic liver malig-nancy, confirmed histologically or clinically, were treated with PTC. After the treatment, all the patientsreceived determination of serum tumor marker, CT scaning and MRI, as well as the ultrasonographyexamination.Results: The survival rate of 12, 18 and 24 months was 81.8% (18/22), 63.6% (14/22)and 22.7% (5/22), respectively.Conclusions: PTC is a microtraumatic, safe and effective method fortreatment of metastatic liver malignancy. It is a good choice for the patients with metastasis of the livercancer that is not suitable for surgical remove.