Abstract: Objective: To discuss the clinical effects and relative complications of Argon Heliumcryoablation during the operation combined with arterial infusion after the operation on advanced pan-creatic cancer.Methods: Argon Helium cryoablation was conducted under the direct sight and by BUltrasonic lead during the operation with 2- 3 Argon Helium probes placed directly to pancreatic tumor,while conducting drainage in gallbladder and intestines and transfer drainage between stomach and in-testines in advanced- stage pancreatic cancer patients who had no operation chance. Transcatheter arte-rial infusion was usually used for 2 to 4 times after the operation. Results: There were 12 cases withover 70% freezing area and 3 with about 50% freezing area. Follow- up: Life span varied from 7 to 18months, with the median of 13.4. The survival rate is 63.6% (7/11). Jaundice disappeared in 7± 2 daysafter operation. One case has biliary fistula, no pancreatic fistula occurred. There was obvious decreasefor tumor markers such as CA₁₉₉, CA₁₂₅, CA₂₄₂ and CA₅₀₄ weeks after the operation, compared withpre-operation (P<0.05).Conclusions: Argon Helium cryoablation during the operation on advanced-stage pancreatic cancer is safe, feasible and effective.