胃间质瘤70例临床诊治分析

The Diagnosis ana Treatment of Gastric Stromal Tumor: Report of 70 Cases

    摘要
  • 摘要: 目的:探讨胃间质瘤的诊治方法及预后。方法:对70例经手术治疗的胃间质瘤的临床资料进行回顾性分析。结果:行远端胃大部切除术16例,近端胃大部切除术22例,胃楔形切除32例。肿瘤平均直径5.4cm,胃周淋巴结转移2例(2.9%)。免疫组化结果CD117阳性66例(94.3%),CD34阳性53例(75.7%),SMA阳性24例(34.3%),Desmin阳性8例,S100阳性8例。术后复发5例,远处转移6例,术后5年生存率为71.3%。良、恶性胃间质瘤组5年生存率分别为92.3%和61.8%(P<0.05)。瘤体直径<5cm与瘤体直径≥5cm组5年生存率分别为95.0%和48.4%(P<0.05)。结论:胃间质瘤的治疗以手术为主,其预后主要与肿瘤大小及肿瘤的良、恶性相关。

     

    Abstract: Objective : To investigate the diagnosis and treatment of gastric stromal tumors (GSTs). Methods : The clinical data of 70 cases with GSTs were analyzed retrospectively. Results : Wedge resections were performed on 32 patients and partial gastrectomies on 38 patients. The median size of tumors is 5.4cm in diameter, 2 of 70 (2.9%) had lymph node metastasis. 66 of 70 (94.3%) were positive for CD117, 53 (75.7%) positive for CD34, 24 positive for SMA, 8 positive for Desmin and S100. 10 of 70 patients recurred or metastasized. The 5-year survival rate in this series was 71.3%. The 5-year survival rate of benign and malignant GSTs were 92.3% and 61.8% (P<0.05). The 5-year survival rate for tumors <5cm and ≥5cm were 95.0% and 48.4% (P<0.05). Conclusions : The primarily treatment of gastric stromal tumor is surgicalE Tumor size and mitotic count were found to be important indicators of the prognosisE

     

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