Abstract: Objective: To investigate opioid analgesic management for cancer patients in extrimis.Methods: A retrospective survey was conducted to analyze cancer pain management in 242 patientswith terminal cancer and to compare opioids application between different groups according to the age,gender and primary site of tumor.Results: Among all cases, 176 (72.73%) received opioid therapy. Inthese patients, 134 (76.14%) took MS-Contin and 28 (15.91%) accepted transdermal fentanyl. Further-more, weak opioids were taken by 14 (7.95%) patients. No patient was died of opioid usage. There wasa significant increase in the total daily mean oral morphine equivalent in male patients, compared tofemale patients (166.67mg vs. 107.66mg). The older the patients were, the lower dose they needed to al-leviate their pain, but there is no significant difference between the groups when compared with dailymean morphine doses. No correlation of primary tumor sites and opioid doses was found.Conclusion:The analgesic management of the terminal cancer patients is reasonable and safe. The males requiremore morphine than females to achieve similar pain relief. Elderly patients tend to alleviate cancer painwith lower dose and primary foci of tumor was not associated with opioid dose.