Abstract: Objective :To investigate the clinical significance of cFN concentrations in gastric carcinoma and precancerous diseases of stomach,and the relationship between the serum cFN concentrations and HP infection. Methods :ELISA was used to detect the serum cFN concentrations in 1177 normal subjects,precancerous diseases of stomach and gastric cancer,and to detect the serum antibodies concentrations and anti-HP in all kinds of gastric diseases. Results :The median concentrations of the serum cFN of gastric cancer were significantly high than normal subjects and gastric benign diseases(P<0.05).There were significantly different between the differentiated gastric cancer and the undifferentiated gastric cancer and were not significantly different between the positive and negative groups of lymphatic metastasis.The difference of the serum cFN median concentrations was not significant between IG-HP negative group and IG-HP positive group in all kinds gastric diseases.But the serum cFN median concentrations of the IG-HP positive group were higher than the IG-HP negative group and gastric cancer group was opposite to the above results. Conclusion :The serum cFN concentrations had a clinically useful potential value for identification between gastric cancer and gastric precancerous diseases.The serum cFN concentrations were related with differentiated degree of gastric cancer and were no statistically significant with metastasis of lymphatic node.No statistical difference is found between the IG-HP negative and the HP positive group in all kinds of gastric diseases.But the serum cFN median concentration in IG-HP positive group is higher than in IG-HP negative group gastric benign diseases group,and gastric cancer group was opposite to the above result.It showed that HP played a difference role in the step of the gastric precancer diseases and gastric cancer,and this will be the focus of further studies.