Abstract: Objective: To study the clinical characteristics and treatment of the patients with pleomorphic xanthoastrocytoma. Methods: The clinical data of 8 patients with pleomorphic xanthoastrocytoma were retrospectively analyzed. Results: The average age of the patients was 23.7 years old. Tumors were located in the cerebral hemisphere and the epileptic seizure was the major clinical manifestation for the tumors. The final diagnosis was dependent on pathological examination. The tumors were totally removed in 5 cases, subtotally in 3 and were treated with radiotherapy and/or chemotherapy in 5. All patients were followed up for 10 months to 5 years. Seizure and headache control were quite satisfactory: In the follow-up, 6 cases were survivals, 2 were relapses and 1 dead. Conclusion: Pleomorphic xanthoastrocytoma is relatively a benign tumor. Epileptic seizure is its main symptom. Radiotherapy should only be used in cases of residual tumor, relapse and malignant degeneration. The outcome of pleomorphic xanthoastrocytoma is usually good.