Abstract: Objective :To detect the expression of hMAM mRNA in bone marrow (BM) of patientswith breast cancer and to determine the relationship between micrometastasis in BM and some molecu-lar markers as well as the prognosis of breast cancer. Methods : The expression of hMAM mRNA in BMof patients with breast cancer was detected using RT-PCR. The expressions of ER, PR, Cath-D andVEGF in cancerous tissues were detected by immunohistochemical s-p method. Results :About 37.3%positive expression rate of hMAM mRNA in 102 patients with stage-ⅠandⅢ breast cancer wasfound. The expression of hMAM in BM was much higher in patients with ER(―)and ER(+)than that ofER(++ 、+++)(P<0.001) and of PR (P<0.05). hMAM expression in BM was significantly positive correlat-ed with Cath-D (P<0.05) and VEGF (P<0.05).There was correlation between the expression of hMAMin BM and the distant metastasis in beast cancer (P<0.05). Conclusions : The micrometastasis in BM iscorrelated with some tumor markers.The patients with positive expression of hMAM in BM have morechance of distant metastasis and may have poor prognosis. The detection of micrometastasis may be oneof the targets to predict the prognosis of breast cancer.