Abstract: Objective: To observe the effect of preoperative chemo-radiotherapy for inflammatory breast cancer. Methods: Twenty-one patients with inflammatory breast carcinoma were treated with a combined-modality approach. The protocol included chemotherapy consisted of cyclophosphamide, pi-rarubicin and 5- fluorouracil or cyclophosphamide, amothopterm and 5-fluorouracil. The same infusion schedule was repeated on day 21, total 3-4 cycles, then radiotherapy. Results: All patients were fol-lowed up at more than 5 years. The follow-up rate was 100.00%. The 3-year and 5-year survival ratewere 42.9% and 23.8% respectively. Conclusion: Use of combined-modality treatment is recommended as a standard of care for inflammatory breast carcinoma.