Abstract: Objective :To explore the value of combined detection with MMP-7,VEGF-D andKAI1 (MVK) in the prognosis of pancreatic carcinoma. Methods : By immunohistochemistry, the ex-pression of MMP-7,VEGF-D and KAI1 was respectively studied and the relationship between co-ex-pression mode of MVK and the survival time of patients with pancreatic carcinoma was analysed. Re-Sults :Different modes of MVK were of statistical significance with patient median survival time(12months, 8 months, 6 months, 5 months, respectively. P=0.0045, P=0.0003, P=0.0015, respectively).COX regression revealed that coexpression mode of MVK is independent prognostic factors in pancreat-ic carcinoma. Conclusions :Combined analysis of MVK may lead to a more reliable prognostic estima-tion, and it deserves further investigation.