PET与EP/CE方案化疗治疗广泛期小细胞肺癌的疗效比较

Efficacy of PET and EP/CE Chemotherapy for Extensive Small Cell Lung Cancer

    摘要
  • 摘要: 目的 :回顾性比较分析PET(Paclitaxel 135mg/m2 d1,VP-1675mg/m2 d1-3,DDP80mg/m2 overd1-3)与EP/CE方案化疗治疗广泛期小细胞肺癌的临床疗效。 方法 :本组68例初治的广泛期小细胞肺癌患者,27例行PET化疗,41例行EP/CE方案化疗,3周重复,共4～6周期,比较两组的临床疗效。 结果 :PET方案组总有效率81.5%,CR29.6%,PR51.9%,中位生存期10.5个月,1年生存率44.4%,2年生存率29.6%。EP/CE方案组总缓解率58.5%,CR22.0%,PR36.6%,中位生存期8.9个月,1年生存率39.0%,2年生存率24.4%。两组间总有效率有显著性差别(P<0.05),而1年生存率、2年生存率无显著性差别(P>0.05)。 结论 :PET方案与EP/CE方案化疗治疗初治的广泛期小细胞肺癌患者远期生存无差别。

     

    Abstract: Objective :To compare the clinical efficacy of PET (Paclitaxel 135mg/m2 d1, VP-1675mg/m2 d1-3, DDP 80mg/m2 over d1-3) with EP/CE chemotherapy for previously untreated extensivesmall cell lung cancer. Methods : A total of 27 patients of extensive small cell lung cancer were treatedwith 4-6 cycles PET regimen, repeated every 3 weeks, and 41 patients with EP/CE regimenchemotherapy. Results :The overall response rate with PET and EP/CE was 81.5% (CR 29.6%. PR51.9%) and 58.5% (CR 22.0%. PR 36.6%), respectively (P<0.05),the MST was 10.5 month and 8.9month,respectively, the 1-, 2-year survival rates were 44.4%, 29.6% and 39.0%,24.4%(P>0.05). Conclusion :There was a statistical difference on overall response rate in PET and EP/CE chemothera-py for extensive small cell lung cancer, but there was no statistical difference on long-term survival.

     

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