摘要:
目的 :总结原发性睾丸非精原细胞性生殖细胞肿瘤(NSGCT)的诊断与治疗体会。 方法 :回顾性分析收治的68例NSGCT临床资料。胚胎癌35例,畸胎瘤11例,卵黄囊瘤3例,绒毛膜上皮癌6例,混合性生殖细胞瘤13例。睾丸无痛性肿大为其主要临床表现。在根治性睾丸切除基础上采用腹膜后淋巴结清扫术(RPLND)及化疗等综合治疗措施。 结果 :全组患者中随访63例,失访5例。睾丸肿瘤的B超诊断优于CT,腹膜后淋巴结的CT诊断优于B超。3、5年生存率与国内外报道相似。 结论 :NSGCT在根治性睾丸切除基础上采用RPLND及化疗等综合治疗措施,疗效满意。B超和CT为其诊断和临床分期的主要手段。肿瘤标记物对治疗以及预后判断有一定参考价值。
Abstract:
Objective :To evaluate the diagnosis and treatment of primary testicular nonsemino-matous germ cell tumors (NSGCT). Methods :Sixty- eight cases of NSGCTs were analyzed. There were35 embryonal carcinomas, 11 teratomas, 3 yolk sac tumors, 6 choriocarcinomas and 13 mixed germ celltumors. The cardinal clinical manifestation was painless solid enlargement of the testis. Combined thera-py, including radical orchiectomy (RO), retroperitoneal lymph node dissection (RPLND) andchemotherapy, was given. Results :Sixty-three patients have been followed up at 3 and 5 years. B-ul-trasound is better than CT in the diagnosis of NSGCT; on the other hand, CT is better than B-ultra-sound in the detection of metastasis to retroperitoneal lymph nodes. Survival rates are similar to reportsat home and abroad. Conclusion :Combined therapy, including RO, RPLND and chemotherapy is sat-isfactory. Clinical staging is based on CT or B-ultrasound. Tumor markers are helpful for diagnosis,prognosis and monitoring the therapeutic effect of treatment on NSGCT.
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