Abstract: Objective : To study the expression of p-PKB, p-Bad and Bim protein and mRNA in the tissues of endometrial carcinoma, and to probe the relationship between this expression and the occurrence of endometrial carcinoma. Methods : Expression of p-PKB, p-Bad and Bim protein were evaluated by immunohistochemistry (SP) in 55 cases of endometrial carcinoma, 13 cases of atypical endometrial hyperplasia and 11 cases of normal proliferative-phase endometrium. The content of PKB, Bad and Bim mRNA in those tissues was evaluated by RT-PCR. Results : p-PKB and p-BAD proteins were expressed more often in the tissues of endometrial carcinoma and atypical endometrial hyperplasia than in normal proliferative-phase endometrium (P=0.001; P0.001). On the contrary, Bim protein was expressed more often in normal tissue (P0.001). The amount of PKB mRNA and Bad mRNA in the three groups show no significant difference, but the amount of Bim mRNA in normal proliferative-phase endometrium is higher than that in endometrial carcinoma and atypical endometrial hyperplasia (P=0.006). Conclusion s: The activation of the PKB pathway is closely related to the occurrence of endometrial carcinoma, and the activated PKB pathway can affect BH3-only proteins, inhibiting their pro-apoptotic ability, resulting in the occurrence of endometrial carcinoma.