Abstract: Objective: To explore the clinic significance of Multi-drug resistant protein expression in patients with nasopharyngeal carcinoma. Methods: Positive expression rates of P-gp and GST-π protein were determined in the 45 patients with nasopharyngeal carcinoma using immunohistochemistry stain. At the same time, the clinical stages of Fuzhou 1992 and histological types of WHO staged in NPC were ascertained. Those patients, with T3~4, N2~3 and T2N1 stages, were treated with induced chemotherapy and radiotherapy; with T3~4, N2~3 stages, were treated with neoadjuvant chemotherapy .Induction chemotherapy consisted of one to two cycles of cisplatin and fluorouracil. RT was given to the nasopharynx and neck using megavoltage radiation. The response of chemotherapy and radiotherapy in NPC patients was evaluated at six months. Results: The expression rate of P-gp was correlated with pathology types and that of GST-π had nothing to do with the pathology types. However, statistical analysis showed an independence between the P-gp and GST-π proteinic expressions and the clinical stage and short-term therapeutic effect. Conclusion: There was no correlation between the expressions of P- gp and GST-π protein and the clinical stage and short-term therapeutic effect.