Abstract: Objective: To research the microvessel density (MVD) and the expression of vascular endothelial growth factor (VEGF) and its receptors (flt-1,KDR) in epithelial ovarian carcinomas, as well as the correlations with several clinicopathologic and demonstrative prognostic parameters. Methods: The immunohistochemical technology was used to detect the expression of VEGF and its receptors (flt1, KDR), and the MVD in 30 specimens of normal ovaries, 30 specimens of benign ovarian tumors and 52 specimens of epithelial ovarian cancer. Results: There was a significant difference between the expression of VEGF in epithelial ovarian cancer in various pathologic grading and clinical stages (F= 4.539, P<0.05; F=6.091, P<0.05). The expressions of flt-1, KDR in vascular endothelial cells and tumor cells of ovarian cancer were significant. The multifactorial Cox regression analysis showed that the size of remaining focus of infection after first operation and MVD was the independent prognostic factors in epithelial ovarian carcinomas (RR=4.462, P<0.05; RR=6.266, P<0.05). The flt-1 and KDR are highly expressed in either vascular endothelial cell or tumor cell. Conclusion: In epithelial ovarian carcinomas, VEGF is an important angiogenic factor. Angiogenesis plays an important role in formation of the ascites in ovarian cancer. Either VEGF or it's receptors are expressed in the tumor cells of epithelial ovarian carcinoma, which confirms VEGF promotes the tumor development through autocrine mode. The MVD is an independent prognostic factor in epithelial ovarian carcinomas.