Abstract: Objective: To observe the therapeutic effect and adverse reaction of preoperative induced hypertension chemotherapy on stage-III carcinoma of gastric cardia or fundus of the stomach. Methods: Forty-nine cases with stage-III carcinoma of gastric cardia or fundus of the stomach were divided into two groups at random. Nineteen cases were included in the experimental group and 30 were in the control group. Each case received one cycle of chemotherapy. A regimen of chemotherapy in addition to AT·was used in the experimental group. A single chemotherapy treatment was administered in the control group. The patients in both groups had surgery 3 weeks after the chemotherapy treatment. The specimens were analyzed for ploidy using flowcytometry. Results: The combined treatment was effective in 63.2% (12/19) of the cases in the experimental group, and the surgical removal rate in that group was 84.2% (16/19). The single treatment was effective in 30% (9/30) of the control group, and the surgical removal rate was 63.3% (19/30). The results of DNA ploidy determination were as follows: there were 13 diploid and 5 aneuploid cases in the experimental group, while there were 9 diploid and 16 aneuploid cases in the controls . Surgery-related complications and associated risk were not significant in either group. Conclusion: IHC can significantly increase the therapeutic effect of treatment for stage-III carcinoma of gastric cardia or fundus of the stomach. IHC is a potential chemotherapeutic regimen that is worthwhile for further clinical study.