Abstract: To evaluate the short- term efficacy of the CHOPE regimen for treatment of advanced NHL. Methods: Eighty cases with advanced NHL were divided evenly into groups. The 40 cases in the control group were treated with the CHOP regimen, i.e. CTX 750mg/m2 ivgtt, dl; VCR1.4 mg/m2 iv, d1; ADM40mg/m2 iv, d1 and Prednisone 100mg/d, d1- 5. The 40 cases in the treatment group were treated with the CHOPE regimen, i.e. CHOP+ VP- 16 100mg/d ivgtt, dl - 3. The duration of one cycle was 21 days. The assessment for clinical effect was conducted for those with completion of 2 cycles of chemotherapy. Results: In the treatment group, there was a complete response in 21 cases, partial response in 12 cases, and no change in 4 cases. Progression of disease occurred in 3 cases, and the overall response rate was 82.5%. Conclusions: The CHOPE regimen can achieve a satisfactory result in the treatment of advanced NHL, and the toxicity was endurable.